Evidence-Based Science

Clinical Trial Results

Discover the data behind NADEssence™. Our commitment to transparency ensures you have access to the rigorous testing and proven efficacy of our NAD+ formulations.

52%
Increase in NAD+ Levels

Observed within the first 5 days of daily supplementation.

60
Participants

Across randomized, double-blind, placebo-controlled clinical study.

5000
Data Points Per Participant

Favorably impacted over 85 biomarkers and 65 metabolic pathways.

Clinical study visualization
science Illustration Purposes Only

Clinically Relevant Outcomes with Use

Our study focused on intracellular increases in NAD+. There were 52 predefined clinical lab tests with 3,000 proteins and 1,500 metabolites observed. There were no statistically significant adverse findings indicating an excellent safety profile.

  • check 52% Increase in treatment group versus placebo (4.5%).
  • check Increased sirtuin 1 (SIRT1) activity.
  • check Confirmed intracellular uptake in cellular mitochondria.
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Liver, Kidney & Oxidative Stress

Results also supported an association between supplementation with NADEssence™ and improved liver and kidney functioning (decreased bilirubin, ALP, serum albumin and GGT) when compared to placebo. GGT, is also a marker of oxidative stress; reductions in GGT may indicate reduced oxidative stress.

p<.05 Favorable liver and kidney function results
"NADEssence™ stands out because it's built on mechanism, not marketing. The science, clinical intent, and manufacturing standards align with what healthcare professionals expect from a truly professional-grade product."
DR
Dr. Fab Mancini, DC
Health and Lifestyle Expert

Clinical FAQ

What is NADEssence™ expand_more
NAD+ is a highly unstable molecule, which in its natural form begins to break down after five days if not kept refrigerated. We use a unique, patented process in manufacturing, ensuring the NAD+ dose is stable on the shelf (two years documented shelf life), within the gut, and in the bloodstream.
How was the RENEWAL Study conducted? expand_more
All our trials adhere to gold-standard methodologies: randomized, double-blind, and placebo-controlled. They were conducted by independent third-party research organizations to ensure unbiased data collection and analysis.
Why you can rely on our measured results? expand_more
We paired a clinical-grade intracellular NAD+ assay with state-of-the-art multiomics profiling to capture both the direct cellular impact of NAD+ supplementation and the resulting cascade of systemic changes.
Is NADEssence™ FDA approved? expand_more
NADEssence™ is a dietary supplement and as such, it is not "approved" by the FDA in the way drugs are. However, NADEssence™ is manufactured in FDA-registered cGMP facilities. And to ensure consistent quality, every lot is tested by an independent, accredited laboratory.
Where can I find more information? expand_more
A summary of the study is available by clicking the link above. If you have additional questions, please contact our medical affairs team.

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